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KMID : 0361019990420080993
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Korean Journal of Otolaryngology - Head and Neck Surgery
1999 Volume.42 No. 8 p.993 ~ p.996
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Effects of Histamine 2 Antagonist in the Treatment of Perennial Allergic Rhinitis
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Lee Kyung-Chul
Kim Dae-Young
Lee Jung-Woo
Kwon Ki-Whan
Jin Sung-Min
Lee Yong-Bae
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Abstract
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Background and Objective :
Clinically, H1 antagonists are beneficial in reliving nasal itching, sneezing, and rhinorrhea in patients with allergic rhinitis. But they have a lesser effect on nasal blockade. Concomitant administration of an H1 antagonist with an H2 antagonist have been reported to improve the symptoms of allergic rhinitis and enhance the wheal suppression in the skin test. The aim of this study was to assess the effect of H2 antagonist in tile management of perennial allergic rhinitis.
Materials and Methods :
60 allergic rhinitis patients with positive skin test was randomly divided by 3 different groups. The groups were H1 antagonist (cetirizine), H2 antagonist (ranitidine), and combination of H1 and H2 antagonist (cetirizine and
ranitidine) group. The clinical response, wheal suppression in the skin test, total serum IgE levels, and serum eosinophil count were measured during the clinical trial.
Results :
There was a significant relief of nasal symptoms, especially nasal obstruction in the combination of H1 and H2 antagonists administered group (p<0.05). And combined therapy with H1 and H2 antagonist reduced the total serum IgE level and increased wheal suppression in skin test (p<0.05). The change in serum eosinophil count was not observed.
Conclusions :
In this study, concomitant administration of H1 antagonist with H2 antagonist with be helpful in the treatment of perennial allergic rhinitis.
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KEYWORD
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Perennial allergic rhinitis, Histamine 2 antagonist,
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